Carboxylic acids and derivatives
Apexbio Technology LLC Pentoxyverine Citrate 23142-01-0 10mM (in 1mL DMSO)
Pentoxyverine Citrate (CAS 23142-01-0) is a small-molecule antagonist targeting acetylcholine receptors (AChR) including 1 and 2 receptors It acts by inhibiting central and peripheral cholinergic pathways thereby regulating neural control of cough reflex sensitivity Pentoxyverine Citrate exerts its biological activity primarily through suppression of the cough reflex via modulation of sensory nerve pathways It demonstrates antitussive anticonvulsant and antispasmodic activity with K i values of 41 nM for 1 894 nM for 2 and 75 nM for 1 receptors in guinea pig brain membrane models Based on these pharmacological properties Pentoxyverine Citrate holds research potential in studies of cough physiology cholinergic neurotransmission and therapeutic interventions in respiratory conditions
![Medchemexpress LLC Acetic acid, 2-[2-(2-azidoethoxy)ethoxy]- | 882518-90-3 | 99.0% | 189.17 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Acetic acid, 2-[2-(2-azidoethoxy)ethoxy]- | 882518-90-3 | 99.0% | 189.17 | 1 MG
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Can be used in the synthesis of PROTACs
- PROTACs utilize the intracellular ubiquitin-proteasome system to degrade target proteins
Medchemexpress LLC Azido-PEG2-CH2COOH | 882518-90-3 | 99.03% | 189.17 | 1 ML
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is a click chemistry reagent containing an Azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs use the intracellular ubiquitin-proteasome system to degrade target proteins.
- PEG-based PROTAC linker.
- Click chemistry reagent.
- Contains an Azide group for CuAAc reaction with Alkyne groups.
- Can undergo SPAAC reactions with DBCO or BCN groups.
Sigma Aldrich Fine Chemicals Biosciences Toremifene citrate salt >=98% (HPLC) | 89778-27-8 | MFCD01729016 | 25MG
Toremifene citrate salt >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 598.08 | 89778-27-8 | MFCD01729016 | 25MG
Medchemexpress LLC CH2COOH-PEG3-CH2COOH | 32775-08-9 | 99.1% | 5 G
CH2COOH-PEG3-CH2COOH is a PEG-based linker bearing two terminal carboxylic acid groups used as a building block in the chemical synthesis of Proteolysis Targeting Chimeras (PROTACs) and other conjugates for research.
- Provides two terminal carboxylic acids for covalent or amide coupling
- Peg3 spacer enhances solubility and flexibility in conjugates
- High listed purity suitable for research use
- Molecular weight 266.25; chemical formula C10H18O8
- Available in small-scale packages for synthetic work
Medchemexpress LLC COR659 | 544450-68-2 | 99.9% | 337.82 | 50 MG
COR659 is a potent and effective GABAB positive allosteric modulator (PAM). It suppresses alcohol and chocolate self-administration in rats. It appears to act through a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
- Potent and effective GABAB positive allosteric modulator (PAM).
- Suppresses alcohol and chocolate self-administration in rats.
- Effective in reducing lever-responses for sucrose and chocolate solutions in rats.
- In vivo studies indicate no effect on lever-responding for regular food pellets in food-deprived Wistar rats.
- Demonstrates a dose-dependent reduction in lever-responses for alcohol in rats.